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Old 09-05-2019, 06:06 PM
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Dave @ ActiveMSers
Join Date: Jun 2008
Location: Albuquerque, NM
Posts: 3,916

I appears oligoclonal banding (OCB) in the CSF is the catch. If it doesn't go away, your MS is almost certainly going to return.

OCB status in MS is very important, and furthermore ridding the body of OCBs, even more so.

So, what is the effect of HSCT on OCB status?

At >1500 day follow-up (~49 months or 4 years), in the 45 participants studied, 98% were OCB positive prior to HSCT. However, 74% remained positive afterwards....

In my opinion, this rate of elimination of the underlying autoimmunity is insufficient to declare HSCT a success, in so far as a cure is concerned. ... This indicates that HSCT has a greater chance of achieving long-term remission in selected individuals, than a cure.
I expect more long-term studies will bear this conclusion out. HSCT is still devastatingly effective for the right patient, but the adage that nothing lasts forever likely holds true for this treatment as well....
Dave Bexfield
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