ActiveMSers Forums  

Go Back   ActiveMSers Forums > ActiveMSers.org Forums > General

Reply
 
Thread Tools Display Modes
  #1  
Old 11-27-2019, 12:30 PM
ActiveMSers's Avatar
ActiveMSers ActiveMSers is offline
Dave @ ActiveMSers
 
Join Date: Jun 2008
Location: Albuquerque, NM
Posts: 3,838
Exclamation An argument for broad use of high efficacy treatments in early multiple sclerosis

For those who are recently diagnosed with MS, this might be the most important paper you'll ever read. -D

Journal of Neurology

An argument for broad use of high efficacy treatments in early multiple sclerosis

James M. Stankiewicz, Howard L. Weiner
First published November 22, 2019, DOI: https://doi.org/10.1212/NXI.0000000000000636

Abstract

Two different treatment paradigms are most often used in multiple sclerosis (MS). An escalation or induction approach is considered when treating a patient early in the disease course. An escalator prioritizes safety, whereas an inducer would favor efficacy.

Our understanding of MS pathophysiology has evolved with novel in vivo and in vitro observations. The treatment landscape has also shifted significantly with the approval of over 10 new medications over the past decade alone. Here, we re-examine the treatment approach in light of these recent developments.

We believe that recent work suggests that early prediction of the disease course is fraught, the amount of damage to the brain that MS causes is underappreciated, and its impact on patient function oftentimes is underestimated. These concerns, coupled with the recent availability of agents that allow a better therapeutic effect without compromising safety, lead us to believe that initiating higher efficacy treatments early is the best way to achieve the best possible long-term outcomes for people with MS.

FULL ARTICLE (FREE):
https://nn.neurology.org/content/7/1/e636
__________________
Dave Bexfield
ActiveMSers
Reply With Quote
  #2  
Old 11-27-2019, 01:30 PM
ActiveMSers's Avatar
ActiveMSers ActiveMSers is offline
Dave @ ActiveMSers
 
Join Date: Jun 2008
Location: Albuquerque, NM
Posts: 3,838
Default

As many of you know, I got a stem cell transplant four years after diagnosis. But the damage had been done. In the spring of 2009 I was an EDSS 3.0. That fall? A 6.0. I barely qualified for the trial at a 5.5. Today? A 7.0 and I use a wheelchair full time.

The transplant held for four years, but if I had been able to initiate stronger treatment earlier, I might still be walking today. Do not underestimate this disease. Do not underestimate the importance of prompt treatment. Do not underestimate the importance of high intensity treatment. Do not.
__________________
Dave Bexfield
ActiveMSers
Reply With Quote
Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Forum Jump


All times are GMT -4. The time now is 04:58 PM.


Powered by vBulletin® Version 3.7.0
Copyright ©2000 - 2020, Jelsoft Enterprises Ltd.
ActiveMSers