ActiveMSers Forums  

Go Back   ActiveMSers Forums > Forums > MS Fitness

Thread Tools Display Modes
Old 05-15-2018, 02:06 PM
ActiveMSers's Avatar
ActiveMSers ActiveMSers is offline
Dave @ ActiveMSers
Join Date: Jun 2008
Location: Albuquerque, NM
Posts: 3,607
Default THESIS: "Exercise enhances ... the formation of myelin" in MS patients

This is a just released doctoral thesis, and a darn interesting one based on the abstract. - D

The Cellular and Molecular Response of Oligodendroglia to Physical Exercise following Demyelination

Yong, Voon Wee
Jensen, Samuel
Committee Member
Pittman, Quentin
Teskey, Cam


While the efficacy of exercise in the management of cardiovascular, lipid, glycemic, and other systemic disorders has been well documented and long studied, the beneficial effect of exercise on the central nervous system (CNS) has only recently gained substantial support from the literature.

Exercise has been shown to initiate pleiotropic mechanisms that increase the functional acuity of many aspects of the CNS, protect against future pathology, and possibly reverse existing disability. While there has been significant study of the effect of exercise on the pathophysiology of neurodegenerative disorders and on general CNS well-being, there has been only limited study of exercise in demyelinating disorders, such as multiple sclerosis (MS), particularly with regard to whether exercise promotes reparative processes.

In this thesis I investigate the effect of exercise on the regeneration of myelin in the lysolecithin model of focal demyelination. I show that exercise enhances oligodendrogenesis and the formation of myelin, substantially accelerating the remyelination process. I show that the activation of a transcriptional coactivation, peroxisome-proliferator activated receptor gamma coactivation 1 alpha (PGC1a), is enhanced by exercise and required for the acceleration of myelin thickening.

I then show that exercise works in combination with clemastine, resulting in functionally complete remyelination of lysolecithin lesions. Moreover, the combination treatment preserves axons. Thus, exercise should have considerable clinical utility in disorders where demyelination is present. Finally, I detail a novel technique for visualizing oligodendrocytes in three-dimensions.

Cumming School of Medicine
University of Calgary

Dave Bexfield
Reply With Quote
Old 05-24-2018, 03:40 PM
hscott72 hscott72 is offline
Optimistic Misfit
Join Date: Jul 2016
Location: Fruitvale BC Canada
Posts: 12
Default I will continue to chant genesis of neurons and oligodendrocytes motivation required

Its good to see confirmation of what I suspected. When my motivation is running dry I remind myself that I must spur genesis of neurons and oligodendrocytes and I'm glad to hear I'm not lying to myself.
Reply With Quote

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Forum Jump

All times are GMT -4. The time now is 11:49 AM.

Powered by vBulletin® Version 3.7.0
Copyright ©2000 - 2019, Jelsoft Enterprises Ltd.