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Old 01-04-2018, 04:52 PM
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Join Date: Jun 2008
Location: Albuquerque, NM
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Default Intense immunosuppression followed by HSCT as a therapeutic strategy in aggressive MS

Mult Scler. 2017 Nov 1:1352458517742532. doi: 10.1177/1352458517742532. [Epub ahead of print]

Intense immunosuppression followed by autologous haematopoietic stem cell transplantation as a therapeutic strategy in aggressive forms of multiple sclerosis.

Mancardi G1, Sormani MP2, Muraro PA3, Boffa G1, Saccardi R4.

In the majority of relapsing multiple sclerosis patients, the disease can be quite easily controlled by already available, approved therapies. There are, however, some aggressive cases who continue to have clinical and magnetic resonance imaging (MRI) activity in spite of the treatment. These are the cases who may now receive benefit from intense immunosuppression followed by autologous haematopoietic stem cell transplantation (aHSCT). In this review, we describe the method and the rationale of aHSCT, the more recently published studies that demonstrate its efficacy in selected multiple sclerosis cases, the problems related to safety and the transplant-related mortality risk of the procedure. A description of the ideal patient who can take advantage of aHSCT is outlined and, finally, the ongoing studies which are near to completion or are close to starting are briefly reported.
Dave Bexfield
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