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Old 10-16-2019, 05:06 PM
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Dave @ ActiveMSers
Join Date: Jun 2008
Location: Albuquerque, NM
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Default Cognitive decline starts early in MS, researchers find

This new study found that over 60% of MSers suffer cognitive decline within 6 years of diagnosis. Treatment has been shown to slow cognitive decline in MS. Exercise has been shown to slow cognitive decline in MS. This is huge. Don't wait. Don't overthink this, especially because your brain might not be humming on all cylinders. Treat. Exercise. Please. -D

Cognitive trajectories in relapsing–remitting multiple sclerosis: A longitudinal 6-year study

Alfredo Damasceno, Luciana Ramalho Pimentel-Silva, Benito Pereira Damasceno, ...
First Published October 11, 2019 Research Article


Information concerning longitudinal cognitive trajectories in multiple sclerosis (MS) is relatively scarce. Moreover, it is unclear which factors are associated with cognitive decline and what is the clinical impact of cognitive impairment (CI) in the long run.

To investigate cognitive trajectories in relapsing–remitting multiple sclerosis (RRMS) patients, analyzing clinical and magnetic resonance imaging (MRI) predictors of cognitive decline.

We enrolled 42 patients and 30 controls. They underwent brain MRI and clinical/neuropsychological evaluation at baseline and after 1, 2, and 6 years. We evaluated cognitive domains with principal component analysis and performed multivariable regression analyzing predictors of clinical/cognitive deterioration. We also performed repeated measures analysis to assess whether clinical progression was different according to CI at baseline.

A total of 23 (62.2%) patients deteriorated in combined cognitive domains after 6 years, most in processing speed and memory. The number of baseline impaired cognitive domains was strongly associated with 6-year cognitive (R2 = 0.452; p < 0.001) and Expanded Disability Status Scale (EDSS) deterioration (R2 = 0.263; p < 0.001). Patients with baseline CI in combined domains had worse clinical progression.

Isolated CI tends to become more widespread, affecting memory and processing speed alongside. The extent of baseline CI was the best predictor of both clinical and cognitive deterioration after 6 years.
Dave Bexfield
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