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Old 10-12-2016, 11:48 AM
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Dave @ ActiveMSers
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Location: Albuquerque, NM
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Default BREAKING: Evidence that exercise repairs brain damage

The full study is a bit heavy for the average reader (including myself) but the bottom line is clear: "Our results suggest that damaged cerebellar neurons can be substantially rescued by increased myelination" and "for the first time, our results provide strong evidence that VGF has the ability to stimulate OP proliferation, trigger myelination, revert neural damage, and prolong lifespan."

Yes, this research was done on mice, not humans. Yes, this research covered only running (it's rather challenging to make mice cycle or play squash). But overall, it is becoming clearer and clearer that aerobic exercise may play a large role in containing multiple sclerosis progression. - D

Running helps repair brain damage in mice, Ottawa researchers find

Researchers at The Ottawa Hospital and the University of Ottawa have discovered that a molecule triggered by running can help repair certain types of brain damage in mice.
The molecule, called VGF nerve growth factor, had previously been discovered to promote an anti-depressant response, but its importance in preventing or delaying brain damage wasn't as clear.

But in a study*published Tuesday in the scientific journal*Cell Reports, the researchers discovered the production of VGF nerve growth factor*assists with the healing of the protective coating that insulates nerve fibres.

The discovery was made when researchers were studying mice with genetically modified cerebellums, the part of the brain that controls motor movement co-ordination and balance. helps to explain the effect that exercises, like running, have on people suffering from neurodegenerative diseases that involve damaged nerve insulation like multiple sclerosis.

....when mice stopped exercising they began to debilitate again.

Voluntary Running Triggers VGF-Mediated Oligodendrogenesis to Prolong the Lifespan of Snf2h-Null Ataxic Mice
Matías Alvarez-Saavedra


•Running promotes the survival of mice with cerebellar ataxia following Snf2h inactivation
•Running ataxic mice show enhanced oligodendrogenesis and de novo myelination
•Comparative RNA-seq studies identify VGF as a contributor to brain repair
•VGF overexpression improves ataxic phenotype in mice without exercise

Exercise has been argued to enhance cognitive function and slow progressive neurodegenerative disease. Although exercise promotes neurogenesis, oligodendrogenesis and adaptive myelination are also significant contributors to brain repair and brain health. Nonetheless, the molecular details underlying these effects remain poorly understood. Conditional ablation of the Snf2h gene impairs cerebellar development producing mice with poor motor function, progressive ataxia, and death between postnatal days 25–45. Here, we show that voluntary running induced an endogenous brain repair mechanism that resulted in a striking increase in hindbrain myelination and the long-term survival of Snf2h cKO mice. Further experiments identified the VGF growth factor as a major driver underlying this effect. VGF neuropeptides promote oligodendrogenesis in*vitro, whereas Snf2h cKO mice treated with full-length VGF-encoding adenoviruses removed the requirement of exercise for survival. Together, these results suggest that VGF delivery could represent a therapeutic strategy for cerebellar ataxia and other pathologies of the CNS.


Dave Bexfield
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Old 10-12-2016, 08:57 PM
Susannah Susannah is offline
Join Date: Nov 2008
Location: Red Feather Lakes, CO
Posts: 83

Oh hell yes! Over the past year on my hikes I've been breaking into a run when the terrain is flat and my legs feel good - I used to be a trail runner and I still get glimpses of that old feeling once in a while. I love it so much that I've started wearing running shoes on my hikes instead of hiking boots, just in case I can run that day. I got an ultra running hydration pack, too. And I wear running clothes instead of hiking clothes. I do this so I can still feel like a trail runner - and look like one when I break into that run. The other day I actually ran for almost half my hike! You mean I can - and should - do this?! Very nice!!
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Old 04-12-2017, 05:24 AM
Stewart Stewart is offline
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Join Date: Jan 2017
Posts: 10
Default question - vgf and other research ?

I just read up on VGF and neuropeptides - simply used Wiki. Very interesting reading - plus research new that links to obesity and other. I have a question - given the plethora of science and testing going on that may have findings someday good for treating ms - is there any one place where all this research etc... is listed in some way sensible (meaning for dummies) ?
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Old 04-15-2017, 10:26 AM
MS Yoda
Join Date: Sep 2009
Location: Colorado
Posts: 826

Stewart, although not MS specific, one idea for finding at least some of the plethora of studies concerning health effects of exercise is a good sports physiology journal. I use the ACSM free journal. Normally only the abstracts are available and a lot of it is a little too specific to be very meaningful but they have a large database that is searchable . I have operated on the premise that if it's good for the general population, it is probably good for the MS population.

Hopefully you can figure out how to get their monthly free publication from this:
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Old 04-17-2017, 04:32 AM
Stewart Stewart is offline
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Join Date: Jan 2017
Posts: 10
Default many thanks - good info source

Thanks much for the tip to Medicine and Science in Sports and exercise. Immediately I discovered very interesting reading with "conclusions" - always needing further investigation of course. I was interested to read vibration training improves disability level; intellectual issues don't impact on fatigue; and sleep likely does impact strongly on fatigue. Woah - so much to digest. The last one - sleep impacts fatigue, exercise gives better sleep - ergo ..
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Old 04-18-2017, 09:08 AM
MS Yoda
Join Date: Sep 2009
Location: Colorado
Posts: 826

And another searchable database, ECTRIMS! Can't believe I didn't think about this one sooner, and this one is MS specific. http://onlinelibrary.ectrims-congres...ia=3*ce_id=891
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