ActiveMSers Forums  

Go Back   ActiveMSers Forums > ActiveMSers.org Forums > MS Fitness

Reply
 
Thread Tools Display Modes
  #1  
Old 04-13-2016, 11:35 AM
ActiveMSers's Avatar
ActiveMSers ActiveMSers is online now
Dave @ ActiveMSers
 
Join Date: Jun 2008
Location: Albuquerque, NM
Posts: 2,981
Default STUDY: Aerobic Exercise Improves Fitness and Cognition in RRMS

Aerobic Exercise Improves Fitness and Cognition in Relapsing Remitting Multiple Sclerosis

Authors

Rebecca Spain, Manoj Sammi, Bharti Garg, Rebecca Kingsland, Kerry Kuehl, William Rooney
Portland, OR, USA

Abstract

OBJECTIVE: To determine the effects of aerobic exercise on cardiovascular fitness, brain function, and novel MRI markers of mitochondrial function.

BACKGROUND: Aerobic exercise increases hippocampal size and improves memory in older adults. Animal models and cross-sectional MS studies of aerobic exercise show improved recovery from relapses and associations with brain substructure volumes. A possible mechanism of action is improved CNS mitochondrial function. We hypothesized that an aerobic exercise intervention would improve fitness, cognition, and fatigue in people with MS. We interrogated the CNS metabolic state using phosphorous MR spectroscopy (31P MRS) to determine CNS mitochondrial function.

DESIGN/METHODS: 11 participants with relapsing MS and no walking limitations used a treadmill at target heart rate for 30 minutes, 4 times per week, for 8 weeks under supervision. Prior to and post-intervention, participants underwent VO2Max testing, 7T 31P MRS of brain and tibialis anterior (TA) muscle during exercise, and phlebotomy. Subjects completed walking tests, Modified Fatigue Impact Scale (MFIS), and Symbol Digits Modality Test (SDMT, cognitive processing speed).

RESULTS: 10 subjects (9 female, age 44.7+/-9.4 years) completed the protocol. One subject was terminated early for recurrent exercise-induced syncope. Mean disease duration was 14.6 +/-6.5 years, and median EDSS was 3.5 (2.5 - 4.0). Resting heart rate, fat mass, and lean mass improved significantly (all p<0.05), as did systolic BP among pre-hypertensive participants (n=4). Significant improvements in SDMT (+7 points, 15%, p <0.05) and the cognitive component of the MFIS (-3.8 points, 26%, p<0.05) were observed. The phosphocreatine recovery constant of the TA muscle improved significantly (27.9%, p<0.05). Brain 31P MRS results and laboratory analyses of serum inflammatory markers will be presented.

CONCLUSIONS: Aerobic exercise improved cardiovascular fitness and cognition in a brief intervention. Aerobic exercise should be considered for cognitive rehabilitation programs.
__________________
Dave Bexfield
ActiveMSers
Reply With Quote
  #2  
Old 04-13-2016, 11:49 AM
ActiveMSers's Avatar
ActiveMSers ActiveMSers is online now
Dave @ ActiveMSers
 
Join Date: Jun 2008
Location: Albuquerque, NM
Posts: 2,981
Default

This was just released at the 2016 AAN conference in New Orleans. If these improvements occurred over just 8 weeks, imagine what a long-term program could do.
__________________
Dave Bexfield
ActiveMSers
Reply With Quote
Reply

Tags
exercise study

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Forum Jump


All times are GMT -4. The time now is 11:45 PM.


Powered by vBulletin® Version 3.7.0
Copyright ©2000 - 2017, Jelsoft Enterprises Ltd.
ActiveMSers