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Old 07-08-2019, 04:56 PM
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Dave @ ActiveMSers
Join Date: Jun 2008
Location: Albuquerque, NM
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Default The effects of high intensity exercise on learning and memory impairments (in rats)

I don't usually put much weight on mice studies, but these are RATS! And sleep-deprived at that. But still, exercise "modulated the destructive effects of sleep deprivation and demyelination on learning and memory" for these little dudes. They were probably living the dream. At least until they were dissected for science and all. -D


International Journal of Neuroscience

The effects of high intensity exercise on learning and memory impairments followed by combination of sleep deprivation and demyelination induced by etidium bromide.

Mohammad Amin Rajizadeh, Vahid Sheibani, Mohammad Abbas Bejeshk, Fatemeh Mohtashami Borzadaran, Hasan Saghari & Khadijeh Esmaeilpour

Received 02 Jan 2019, Accepted 11 Jun 2019, Accepted author version posted online: 05 Jul 2019


Introduction: MS (Multiple Sclerosis) is a chronic inflammatory demyelinating disease of the central nervous system. Cognitive impairments occurs in MS patients including learning and memory impairments. More than 50% of MS patients suffer from sleep problems. It has been suggested that in animal models exercise has direct neuroprotective effects on MS and sleep deprivation (SD). In this research MS impairments were induced using a demyelination model as an indicator of MS disease. Also induction of SD was done using multiple platform. In order to focus on the research question, combination of MS model with SD was studied. In this study, the impact of treadmill exercise on learning and memory impairments was investigated.

Methods: Male wistar rats were used in the present study. Exercise groups exercised daily for 1h/day for 10 consecutive days with treadmill. (Speed: 18m/min &inclination: 25░). The multiple platform method was applied for the induction of a 72h SD. The cognitive functions were evaluated using Morris water maze (MWM) and open field tests. Animals were anaesthetized with a certain dose of ketamine and xylazin. After full anesthesia, the rat was placed on rat stereotaxic instrument in the skull-flat position. Demyelination was induced bilaterally by direct single injection of 3 Ál of 0.01% ethidium bromide in sterile 0.9% saline at the rate of 1Ál/min into the hippocampal formation. The dose was injected using appropriate stereotaxic coordinates.

Result: All of the learning and memory indices in the MWM task showed that SD and hippocampal demyelination destroy learning and memory. It seems that exercise can modulate the destructive effects of SD and demyelination on learning and memory at the behavioral level.
Dave Bexfield
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