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Old 07-24-2018, 12:55 PM
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Default STUDY: Effect of Interval Exercise Training on Fatigue, Depression, Fitness in MS

Effect of Short-Term Interval Exercise Training on Fatigue, Depression and Fitness in Normal Weight vs. Overweight person with Multiple Sclerosis

Raoof Negaresh, Robert Motl, Motahare Mokhtarzade

DOI: https://doi.org/10.1016/j.explore.2018.07.007

Highlights

•Exercise is a therapeutic method for improving fatigue and depression.
•Fatigue and depression improvement after exercise is independent to initial weight status.
•Enhancing fitness level can affect on the psychological parameters improvement.

Abstract

Context
Excessive weight is a health problem that can exacerbate multiple sclerosis (MS) symptoms and its associated comorbidities such as depression and fatigue. In addition, weight may be a moderator of exercise effects on depression and fatigue symptoms.

Objective
This study aimed to investigate the effects of exercise training on fatigue and depression in normal and overweight individuals with MS.

Methods
Sixty-six persons with MS were randomly assigned into an exercise or control condition based on body weight status (overweight vs. normal-weight). The exercise conditions involved 8-weeks of interval exercise at 60-75% Wattpeak, while the control condition did not involve any exercise. Fatigue, depression, aerobic capacity, time up and go (TUG) and body mass index were measured before and following the 8-week period.

Results
There were no significant relationship's revealed for weight status interactions for any of the variables examined. There were significant condition main effects for fatigue, depression, aerobic capacity and TUG, and significant improvements were noted for the exercise conditions, but not in the non-exercising control group.

Conclusion
The results from this study confirm that exercise is an effective therapeutic intervention for improving fatigue, depression and functional parameters, independent of initial weight status, in persons with MS.

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