ActiveMSers Forums  

Go Back   ActiveMSers Forums > ActiveMSers.org Forums > Dave's SCT Journey

Reply
 
Thread Tools Display Modes
  #1  
Old 06-26-2018, 11:19 AM
ActiveMSers's Avatar
ActiveMSers ActiveMSers is offline
Dave @ ActiveMSers
 
Join Date: Jun 2008
Location: Albuquerque, NM
Posts: 3,429
Default HSCT for autoimmune diseases – Clinical experience and mechanisms

Journal of Autoimmunity
Available online 20 June 2018

Hematopoietic stem cell therapy for autoimmune diseases – Clinical experience and mechanisms

Tobias Alexandera, , , Dominique Fargeb, c, Manuela Badogliod, James O. Lindsaye, f, Paolo A. Murarog, John A. Snowdenh

https://doi.org/10.1016/j.jaut.2018.06.002

Highlights
•HSCT has the potential to induce sustained clinical remissions in autoimmune diseases (AD) by restoring self-tolerance.
•The majority of procedures are autologous HSCT, with an evolving base in MS, systemic sclerosis and Crohn’s disease.
•The principle of HSCT is based on depletion of the pathogenic autoreactive repertoire and enabling immunologic renewal.
•Immunologic renewal provides a diverse repertoire of naïve T- and B-cells, including restoration of regulatory cells.
•HSCT requires careful patient selection and multidisciplinary team working between hematology and AD specialists.

Abstract
With accumulating evidence and improved outcomes along with recognition that modern biological therapies are not universally effective, require chronic administration and have high acquisition costs, hematopoietic stem cell transplantation (HSCT) has become an emerging direction for cell therapy in autoimmune diseases (ADs).

The goal of this therapy is to induce medication-free remissions by resetting the immune system into a naïve and self-tolerant state through eradication of the autoreactive immunologic memory and profound re-configuration of the immune system induced by the transplant procedure. Safety of HSCT has generally improved by implementing internal quality management and external accreditation. Inter-disciplinary guidelines for patient selection, transplant technique and supportive care along with greater center experience should optimize safe and appropriate delivery of HSCT in specific ADs.

In this review, we discuss the current role and future perspectives of HSCT in AD, focusing on recent published clinical and scientific studies and recommendations in the field.

https://www.sciencedirect.com/scienc...96841118301823
__________________
Dave Bexfield
ActiveMSers
Reply With Quote
Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Forum Jump


All times are GMT -4. The time now is 12:24 PM.


Powered by vBulletin® Version 3.7.0
Copyright ©2000 - 2018, Jelsoft Enterprises Ltd.
ActiveMSers