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Old 12-16-2019, 03:16 PM
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Default Safety and efficacy of autologous HSCT for MS in Norway

Mult Scler. 2019 Dec 13 [Epub ahead of print]

Safety and efficacy of autologous hematopoietic stem cell transplantation for multiple sclerosis in Norway.

Kvistad S, Lehmann A, et al
Abstract

BACKGROUND:
Hematopoietic stem cell treatment (HSCT) is a promising treatment option for multiple sclerosis (MS), but detailed safety and efficacy measures are still scarce.

OBJECTIVE:
To evaluate the efficacy and safety of HSCT in MS.

METHODS:
Retrospective single-center observational study of all MS patients that underwent HSCT in Norway during January 2015 to January 2018. The primary outcome was no evidence of disease activity (NEDA-3) status.

RESULTS:
A total of 30 patients with a median follow-up time of 26 months (range: 11-48) were evaluated. In total, 25 (83%) achieved NEDA-3 status, and none received disease-modifying treatment after HSCT. For 13 (43%) of the patients, there were sustained improvement in Expanded Disability Status Scale (EDSS) score, and 10 (33%) were working full time after the treatment, compared to only 1 (3%) before treatment. There were no serious treatment-related complications and was no mortality. Five patients (17%) were diagnosed with an autoimmune thyroid disease after the procedure, and 10 (43%) of the women had amenorrhea lasting >12 months and symptoms of ovarian failure.

CONCLUSION:
HSCT in MS is an effective and relatively safe treatment option, with few serious complications and no mortality in Norway, so far. However, long-term adverse event with amenorrhea is a common problem.
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