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Old 02-04-2020, 03:02 PM
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ActiveMSers ActiveMSers is offline
Dave @ ActiveMSers
Join Date: Jun 2008
Location: Albuquerque, NM
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Default Brain atrophy and employment in multiple sclerosis patients: 10-year follow-up study

How important is preserving your brain volume? Critically. Exercise and DMTs help in that department. -D

Brain atrophy and employment in multiple sclerosis patients: a 10-year follow-up study

Cecilie Jacobsen, Robert Zivadinov, Kjell-Morten Myhr, et al

First Published January 27, 2020 Research Article


Multiple sclerosis is often associated with unemployment. The contribution of grey matter atrophy to unemployment is unclear.

To identify magnetic resonance imaging biomarkers of grey matter and clinical symptoms associated with unemployment in multiple sclerosis patients.

Demographic, clinical data and 1.5 T magnetic resonance imaging scans were collected in 81 patients at the time of inclusion and after 5 and 10 years. Global and tissue-specific volumes were calculated at each time point. Statistical analysis was performed using a mixed linear model.

At baseline 31 (38%) of the patients were unemployed, at 5-year follow-up 44 (59%) and at 10-year follow-up 34 (81%) were unemployed. The unemployed patients had significantly lower subcortical deep grey matter volume (P < 0.001), specifically thalamus, pallidus, putamen and hippocampal volumes, and cortical volume (P = 0.011); and significantly greater T1 (P < 0.001)/T2 (P < 0.001) lesion volume than the employed patient group at baseline. Subcortical deep grey matter volumes, and to a lesser degree cortical volume, were significantly associated with unemployment throughout the follow-up.

We found significantly greater atrophy of subcortical deep grey matter and cortical volume at baseline and during follow-up in the unemployed patient group. Atrophy of subcortical deep grey matter showed a stronger association to unemployment than atrophy of cortical volume during the follow-up.
Dave Bexfield
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Old 02-04-2020, 03:42 PM
Suebee Suebee is offline
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Join Date: Mar 2015
Location: Houston, TX
Posts: 471

Dave thanks for posting this. I'd be interested to know what proportion, if any of these patients, qualified for SSdi or LTD under employer plans, and if age or gender had any correlation to patients who did recieve benefits. One can hope that the invisible aspects of MS will become more visible with measurements of brain atrophy and studies like this. I hope data will include such social history measures so that the financial burden on MSers and possible biases by decision makers are exposed as much as the physical changes in the MS brain.
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Old 02-12-2020, 10:59 PM
ThailandVal ThailandVal is offline
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Join Date: Mar 2019
Location: Ayutthaya the ancient capital
Posts: 8

I suspect it works both ways. People whose brains are shrinking are less likely to have a job, and they feel and seem less capable, but also people who do have a job are forced to do more mental work, are more active, and hence their brains are shrinking less, or shrinking more slowly
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Old 02-13-2020, 11:11 PM
Suebee Suebee is offline
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Join Date: Mar 2015
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Default Brain shrink is real

Youíre definitely right that inactive passivity can lead to brain atrophy similar to that seen in aging. But brain atrophy measures have been recognized for awhile now to directly to correlate to neurgeneration in certain disease processes, especially MS. Doctors look at pace of atrophy, area of brain, location of prior plaque, and if it is disproportinate to other atrophy in the brain or age. This can be an important marker to MSers with secondary Progressive course, effectiveness of DMD, and a measurable difference to monitor. I point this out because neurologists donít always discuss these findings with patient. Also Radiologists canít provide comparisons if mris are from different labs or scan techniques. Something to keep in mind if one has a choice to have an mri at different facilities. But If you have had MS for multiple years, this is a valid question to raise with neurologist about atrophy to understand How your brain is faring.

Link to article about aging vs neurodengenartive disease
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