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Risk tolerance and DMTs: A survey of MSers

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  • Risk tolerance and DMTs: A survey of MSers

    No surprises here: risk takers tend to be men, younger and more disabled. -D

    March 13, 2019

    A survey of risk tolerance to multiple sclerosis therapies

    Robert J. Fox, Carol Cosenza, Lauren Cripps, Paul Ford, MaryBeth Mercer, Sneha Natarajan, Amber Salter, Tuula Tyry, Stacey S. Cofield
    First published March 13, 2019, DOI: https://doi.org/10.1212/WNL.0000000000007245

    Abstract

    Objective
    To determine tolerance to various risk scenarios associated with current multiple sclerosis (MS) therapies.

    Methods
    People with MS from the North American Research Committee on Multiple Sclerosis Registry's online cohort and the National Multiple Sclerosis Society were invited to complete a questionnaire on tolerance to real-world risks associated with a hypothetical therapy. Multiple risks levels were presented, including skin rash, infection, kidney injury, thyroid injury, liver injury, and progressive multifocal leukoencephalopathy (PML).

    Results
    Both PML and kidney injury had the lowest risk tolerance (RT) at 1:1,000,000, and thyroid and infection risks had the highest tolerance at 1:1,000. Men, younger individuals, and participants with greater disability reported a higher tolerance to all risk scenarios. Those who were currently taking an MS therapy reported higher tolerance than those not taking any therapy. Participants taking infusion therapies reported high tolerance to all risks, and those taking injectables reported a lower tolerance.

    Conclusion
    People with MS displayed a wide range of RT for MS therapies. Our study identified sex, age, disability, and current disease-modifying therapy use to be associated with RT.
    Dave Bexfield
    ActiveMSers

  • #2
    The full article is available to read as a pdf.

    https://n.neurology.org/content/neur...07245.full.pdf
    Dave Bexfield
    ActiveMSers

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