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STUDY: Physical activity and associated levels of disability and QOL in MSers

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  • STUDY: Physical activity and associated levels of disability and QOL in MSers

    BMC Neurol. 2014 Jul 12;14(1):143. [Epub ahead of print]

    Physical activity and associated levels of disability and quality of life in people with multiple sclerosis: a large international survey.

    Marck CH, Hadgkiss EJ, Weiland TJ, van der Meer DM, Pereira NG, Jelinek GA.

    Abstract

    BACKGROUND:

    Multiple Sclerosis (MS) is a common neurodegenerative disease, which often has a devastating effect on physical and emotional wellbeing of people with MS (PwMS). Several studies have shown positive effects of physical activity (PA) on disability, health related quality of life (HRQOL), and other outcomes. However, many studies include only people with mild disability making it difficult to generalize findings to those with moderate or severe disability. This study investigated the associations between PA and HRQOL, relapse rate (RR), disability, and demographic variables in PwMS with varying disability.

    METHODS:

    Through online platforms this large international survey recruited 2232 participants with MS who completed items regarding PA, MS and other health characteristics.

    RESULTS:

    PwMS who were younger (p < .001), male (p = 0.006), and with lower body mass index (BMI) (p < .001) undertook more PA, which was associated with decreased disability (p < 0.001) and increased HRQOL measures (all p < 0.001). For the subsample of people with relapsing-remitting MS, PA was associated with a decreased RR (p = 0.009). Regression analyses showed that increased PA predicted clinically significant improvements in HRQOL while controlling for level of disability, age and gender. More specifically, increasing from low to moderate and to high PA increased estimated mean physical health composite from 47.7 to 56.0 to 59.9 respectively (25.6% change), mental health composite from 60.6 to 67.0 to 68.8 (13.5% change), energy subscale from 35.9 to 44.5 to 49.8 (38.7% change), social function subscale from 57.8 to 66.1 to 68.4 (18.3% change), and overall QOL subscale from 58.5 to 64.5 to 67.7 (15.7% change).

    CONCLUSIONS:

    For PwMS, regardless of disability level, increased PA is related to better HRQOL in terms of energy, social functioning, mental and physical health. These are important findings that should be taken into consideration by clinicians treating PwMS.
    Dave Bexfield
    ActiveMSers

  • #2
    Here's an interesting take on the study by one of my favorite MS blogger researchers:

    http://multiple-sclerosis-research.b...isability.html

    He poses an interesting conundrum, one I am constantly working at....

    "Exercise is the old chestnut; how do you change population behaviour for the good. Is there something we can use to nudge people in the right direction? Would mass exercise monitoring with rewards for those adhering to their exercise programme work? Any ideas? Crack this problem and we will solve a lot of the health problems of the general population."

    Ideas from fellow ActiveMSers?
    Dave Bexfield
    ActiveMSers

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