STUDY: Regular exercise promotes memory function, enhance neuroplasticity (EAE)
Yes, it's just mice, but this shows the science behind how exercise may benefit those with MS. - D
Regular exercise promotes memory function and enhances hippocampal neuroplasticity in experimental autoimmune encephalomyelitis mice
Tae-Woon Kim, Yun-Hee Sung
•Regular exercise alleviated memory deficits in EAE mice.
•Regular exercise improved markers of myelination in EAE mouse hippocampus.
•Regular exercise improved markers of neurogenesis and proliferation in EAE mice.
•Regular exercise reduced apoptosis in the dentate gyrus of EAE mice.
Multiple sclerosis (MS) is a progressive condition affecting the central nervous system (CNS), and is characterized by the development of demyelinated lesions and plaques in the brain and spinal cord. Exercise is beneficial against dementia in elderly patients, so we investigated the effects of exercise on memory in relation to hippocampal demyelination and neuroplasticity in a mouse model of MS (experimental autoimmune encephalomyelitis [EAE]). Mice were randomly divided into three groups: Sham, EAE, and EAE and exercise (EAE*+*EX). EAE*+*EX mice exercised five times a week for 4*weeks, and all mice performed step-down avoidance tasks in order to verify memory ability. We analyzed changes in myelin basic protein (MBP), 2′,3′-Cyclic nucleotide 3′-phosphodiesterase (CNPase), 5-bromo-2′-deoxyuridine (brdU), doublecortin (DCX), bcl-2, bax, TUNEL, caspase-3, and brain derived neurotrophic factor (BDNF) via immunoassay or histological staining. We found decreased memory ability in EAE mice, accompanied by impaired myelination, increased apoptosis and cell proliferation, and decreased BDNF in the hippocampus. The memory decline and changes in demyelination, apoptosis, BDNF, and cell proliferation were partially reversed in EAE*+*EX mice. Our findings suggest that in patients with MS, regular exercise may benefit cognitive function by rescuing some hippocampal cellular and molecular impairments.
BDNF, brain-derived neurotrophic factor; BrdU, 5-bromo-2′-deoxyuridine; CFA, complete Freund's adjuvant; CNPase, 2′,3′-Cyclic nucleotide 3′-phosphodiesterase; CNS, central nervous system; DCX, doublecortin; DG, dentate gyrus; EAE, experimental autoimmune encephalomyelitis; EX, exercise; MBP, myelin basic protein; MS, Multiple sclerosis; NeuN, neuronal nucleic; PBS, phosphate-buffered saline; PTS, pertussis toxin