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Old 06-08-2017, 05:21 PM
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Dave @ ActiveMSers
Join Date: Jun 2008
Location: Albuquerque, NM
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Default STUDY: Reconstitution of immune cell populations in MSers after AHSCT

Some data from HALT-MS is used here. When I applied for the study I was an EDSS 4.0 apparently, but dropped to a 5.5 in the months waiting for insurance. I would have thought my baseline would have therefore been the higher number. I think I'm HALT_324300.

Reconstitution of immune cell populations in multiple sclerosis patients after autologous stem cell transplantation


F. G. Karnell,
D. Lin,
S. Motley,
T. Duhen,
N. Lim,
D. J. Campbell,
L. A. Turka,
H. T. Maecker,
K. M. Harris
First published: 7 June 2017Full publication history
DOI: 10.1111/cei.12985 *View/save citation
Cited by (CrossRef): 0 articles

Multiple sclerosis is an inflammatory T cell-mediated autoimmune disease. In a Phase II clinical trial, high-dose immunosuppressive therapy combined with autologous CD34+ haematopoietic stem cell transplant resulted in 692% of subjects remaining disease-free without evidence of relapse, loss of neurological function or new magnetic resonance imaging (MRI) lesions to year 5 post-treatment.

A combination of CyTOF mass cytometry and multi-parameter flow cytometry was used to explore the reconstitution kinetics of immune cell subsets in the periphery post-haematopoietic cell transplant (HSCT) and the impact of treatment on the phenotype of circulating T cells in this study population.

Repopulation of immune cell subsets progressed similarly for all patients studied 2 years post-therapy, regardless of clinical outcome. At month 2, monocytes and natural killer (NK) cells were proportionally more abundant, while CD4 T cells and B cells were reduced, relative to baseline. In contrast to the changes observed at earlier time-points in the T cell compartment, B cells were proportionally more abundant and expansion in the proportion of naive B cells was observed 1 and 2 years post-therapy. Within the T cell compartment, the proportion of effector memory and late effector subsets of CD4 and CD8 T cells was increased, together with transient increases in proportions of CD45RA-regulatory T cells (Tregs) and T helper type 1 (Th1 cells) and a decrease in Th171 cells.

While none of the treatment effects studied correlated with clinical outcome, patients who remained healthy throughout the 5-year study had significantly higher absolute numbers of memory CD4 and CD8 T cells in the periphery prior to stem cell transplantation.

Dave Bexfield
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