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Old 03-09-2020, 05:55 PM
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Default Changing Your Gut Microbia to Fight MS: Does it Matter?

Evidence from this latest study suggests once the disease has been established, no. -D

"The data presented here show that, in the context of CNS autoimmunity, microbiota manipulation is beneficial prior to the disease development but not after established disease. Our data reinforce observations that microbiota manipulations through antibiotics and diet have an impact on inflammatory immune responses that are necessary for the induction of the disease [6, 8,9,10] while having minimal impact on remyelination processes that are important for the resolution of the disease."

Published: 06 March 2020

Perturbation of gut microbiota decreases susceptibility but does not modulate ongoing autoimmune neurological disease

Clemens Gödel, Birgit Kunkel, Alireza Kashani, Hans Lassmann, Manimozhiyan Arumugam & Gurumoorthy Krishnamoorthy

Journal of Neuroinflammation volume 17, Article number: 79 (2020) Cite this article

Abstract

The gut microbiota regulates the host immune and nervous systems and plays an important role in the pathogenesis of autoimmune neurological disease multiple sclerosis (MS). There are considerable efforts currently being undertaken to develop therapies for MS based on the modulation of microbiota.

Evidence from experimental models suggests that the manipulation of microbiota through diet or antibiotics prior to the disease development limits disease susceptibility. However, it is currently unclear if microbiota manipulation therapies would also have an impact on ongoing neurological disease.

Here, we examined the effect of antibiotic-based microbiota modulation in spontaneous experimental autoimmune encephalomyelitis (EAE) mouse models of MS before and after the onset of autoimmune disease. Prophylactic antibiotic treatment led to a significant reduction of susceptibility to spontaneous EAE. In contrast, antibiotic treatment after the onset of spontaneous EAE did not show a significant amelioration.

These results reveal that the perturbation of gut bacteria alters disease susceptibility but has minimal impact on the ongoing neurological disease.

FULL ARTICLE (FREE):
https://jneuroinflammation.biomedcen...74-020-01766-9
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