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STUDY: High-intensity resistance training in MS - An exploratory study

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  • STUDY: High-intensity resistance training in MS - An exploratory study

    J Neurol Sci. 2016 Mar 15;362:251-7. doi: 10.1016/j.jns.2016.01.063. Epub 2016 Feb 3.

    High-intensity resistance training in multiple sclerosis - An exploratory study of effects on immune markers in blood and cerebrospinal fluid, and on mood, fatigue, health-related quality of life, muscle strength, walking and cognition.

    Kierkegaard M1, Lundberg IE2, Olsson T3, Johansson S4, Ygberg S5, Opava C6, Holmqvist LW7, Piehl F8.

    Abstract

    BACKGROUND:

    High-intensity resistance training is unexplored in people with multiple sclerosis.

    OBJECTIVES:

    To evaluate effects of high-intensity resistance training on immune markers and on measures of mood, fatigue, health-related quality of life, muscle strength, walking and cognition. Further, to describe participants' opinion and perceived changes of the training.

    METHODS:

    Twenty patients with relapsing-remitting multiple sclerosis performed high-intensity resistance training at an intensity of 80% of one-repetition maximum, twice a week for 12 weeks. Blood and optional cerebrospinal fluid samples, and data on secondary outcome measures were collected before and after intervention. A study-specific questionnaire was used for capturing participants' opinion.

    RESULTS:

    Seventeen participants completed the study. Plasma cytokine levels of tumor necrosis factor were significantly decreased post-intervention (p=0.001). Exploratory cytokine analyses in cerebrospinal fluid (n=8) did not reveal major changes. Significant and clinically important improvements were found in fatigue (p=0.001) and health-related quality of life (p=0.004). Measures of mood (p=0.002), muscle strength (p≤0.001), walking speed (p=0.013) and cognition (p=0.04) were also improved. A majority of participants evaluated the training as very good and perceived changes to the better.

    CONCLUSION:

    High-intensity resistance training in persons with relapsing remitting multiple sclerosis with low disability had positive effects on peripheral pro-inflammatory cytokine levels, led to clinically relevant improvements in measures of fatigue and health-related quality of life, and was well tolerated. These results provide a basis for a larger randomized trial.
    Dave Bexfield
    ActiveMSers
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