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Wearable inertial sensors highly sensitive in the detection of gait disturbances, fatigue in MS

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  • Wearable inertial sensors highly sensitive in the detection of gait disturbances, fatigue in MS

    BMC NeurologyWearable inertial sensors are highly sensitive in the detection of gait disturbances and fatigue at early stages of multiple sclerosisBMC Neurology volume 21, Article number: 337 (2021)

    Abstract

    Background
    The aim of the current study was to examine multiple gait parameters obtained by wearable inertial sensors and their sensitivity to clinical status in early multiple sclerosis (MS). Further, a potential correlation between gait parameters and subjective fatigue was explored.

    Methods
    Automated gait analyses were carried out on 88 MS patients and 31 healthy participants. To measure gait parameters (i.e. walking speed, stride length, stride duration, duration of stance and swing phase, minimal toe-to-floor distance), wearable inertial sensors were utilized throughout a 6-min 25-ft walk. Additionally, self-reported subjective fatigue was assessed.

    Results
    Mean gait parameters consistently revealed significant differences between healthy participants and MS patients from as early as an Expanded Disability Status Scale (EDSS) value of 1.5 onwards. Further, MS patients showed a significant linear trend in all parameters, reflecting continuously deteriorating gait performance throughout the test. This linear deterioration trend showed significant correlations with fatigue.

    Conclusions
    Wearable inertial sensors are highly sensitive in the detection of gait disturbances, even in early MS, where global scales such as the EDSS do not provide any clinical information about deviations in gait behavior. Moreover, these measures provide a linear trend parameter of gait deterioration that may serve as a surrogate marker of fatigue. In sum, these results suggest that classic timed walking tests in routine clinical practice should be replaced by readily and automatically applicable gait assessments, as provided by inertial sensors.

    STUDY (FREE): https://bmcneurol.biomedcentral.com/...83-021-02361-y
    Dave Bexfield
    ActiveMSers
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