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STUDY: Tysabri users "walk and talk" better after one year of treatment

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  • STUDY: Tysabri users "walk and talk" better after one year of treatment

    Eur Neurol. 2014 Feb 1;71(5-6):149-153. [Epub ahead of print]

    Dual-Task Assessment in Natalizumab-Treated Multiple Sclerosis Patients.
    Allali G, Laidet M, Assal F, Chofflon M, Armand S, Lalive PH.

    Abstract

    Background: To study the 1-year evolution of quantitative dual-task gait parameters in comparison with single-task gait parameters and detailed neuropsychological assessment in patients with multiple sclerosis (MS) treated with natalizumab.

    Methods: Walking speed, stride length and stride time during a dual task (walking while forward counting, backward counting, semantic fluency, and phonemic fluency), a single walking task, and a detailed neuropsychological assessment were prospectively measured and assessed twice at the 1-year interval in 9 consecutive patients with MS treated with natalizumab.

    Results: Dual-task-related gait changes (walking speed, stride length and stride time while performing semantic fluency and walking speed, and stride time while performing phonemic fluency) showed a significant improvement after 1 year of treatment with natalizumab. The single walking task and detailed neuropsychological assessment did not present any modification.

    Conclusions: Dual-task-related gait changes using a cognitive task with a specific executive demand represent an interesting marker of disease-modifying therapy in patients with MS.
    Dave Bexfield
    ActiveMSers
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