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B2M Protein associated with memory loss

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  • B2M Protein associated with memory loss

    Recent science news from Europe Newsweek:
    "Studies conducted by neuroscientist Saul Villeda at the University of California, San Francisco have documented the effects of the beta-2-microglobulin protein, otherwise known as the B2M protein, on the memory of mice. ...

    The B2M protein is found in higher quantities in the cerebrospinal fluid (CNS) of the elderly and is thought to be a major contributor to memory loss, dementia and Alzheimer's.


    Villeda expanded on this initial research by pinpointing the B2M protein as a dominant cause of cognitive health deterioration. The B2M immune protein is normally involved in fighting diseases as well as building neurological pathways and is found in higher rates in people with cognitive disorders and Alzheimer's.

    Having identified B2M as potentially being a major factor in terms of the aging of the brain, the scientists then tested its effect on mice.
    This research is a major breakthrough in the medical understanding of how the human mind ages and what factors contribute to cognitive and memory disorders. New Scientist reports Villeda and his team have now begun looking into drugs, antibodies or molecules, that might be used to block the effects of B2M, or indeed block the protein entirely.

    The Mayo Clinic in Minnesota associates an increase in B2M protein in diseases with chronic inflammation, liver disease, some acute viral infections and a number of cancers. It is also associated with diseases that have a large cell turn over, like HIV and other Autoimmune diseases.

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