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STUDY: High HDL levels suppress blood brain barrier injury

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  • STUDY: High HDL levels suppress blood brain barrier injury

    Two ways to boost HDL include exercise and (moderate) alcohol intake. Two things I enjoy!. (FYI, The Mayo clinic has these suggestions: http://www.mayoclinic.org/diseases-c...-20046388?pg=2)

    High HDL levels suppress blood brain barrier injury following the first demyelinating event

    K. Fellows1, T. Uher2, R.W. Browne3, B. Weinstock-Guttman4, D. Horakova2, H. Posova5, M. Vaneckova6, Z. Seidl6, J. Krasensky6, M. Tyblova2, E. Havrdova2, R. Zivadinov4, M. Ramanathan1,4
    1Pharmaceutical Sciences, State University of New York, Buffalo, NY, United States, 2Department of Neurology and Center of Clinical Neuroscience, Charles University in Prague, Prague, Czech Republic, 3Department of Biotechnical and Clinical Laboratory Sciences, State University of New York, Buffalo, 4Department of Neurology, State University of New York, Buffalo, NY, United States, 5Institute of Immunology and Microbiology, 6Department of Radiology, Charles University in Prague, Prague, Czech Republic

    Objectives: To investigate the associations of serum cholesterol and apolipoproteins with measures of blood brain barrier (BBB) permeability and central nervous system (CNS) inflammation following the first clinical demyelinating event.

    Methods: This study included 154 patients (67% female, age: 29.5 SD 8.2 years) enrolled in a multi-center study of interferon beta-1a (IFN) treatment following the first demyelinating event suggestive of multiple sclerosis (MS). Blood and cerebrospinal fluid (CSF) were obtained at screening prior to corticosteroid or IFN treatment. A comprehensive serum lipid profile including cholesterol and apolipoprotein levels was obtained. Multiple surrogate markers of BBB breakdown and CNS immune activity in CSF were obtained including: total protein, albumin, IgG, IgM and CSF-restricted oligoclonal bands. The frequencies of CD80+, CD80+CD19+, CD4+, CCR5+ and CXCR3+ cell subsets in CSF were obtained by flow cytometry. Regression analyses were used to assess the associations between the lipid profile variables and CSF BBB breakdown and immune activity measures.

    Results: Higher serum high density lipoprotein cholesterol (HDL-C) levels were associated with lower CSF total protein level, CSF albumin level, albumin quotient and CSF IgG level. Higher apolipoprotein A1, the characteristic apolipoprotein of HDL, was also associated with lower BBB permeability. CSF CD80+ and CD80+CD19+ cell frequencies were negatively associated with HDL-C levels.

    Conclusions: Higher serum HDL is associated with lower levels of BBB injury and decreased CD80+ cell extravasation into the CSF. HDL may potentially inhibit the initiation and/or maintenance of pathogenic BBB injury following the first demyelinating event.

    Dave Bexfield
    ActiveMSers
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