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High-dose Vitamin D supplement (12K IUs) no better than 1,000 IUs

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  • High-dose Vitamin D supplement (12K IUs) no better than 1,000 IUs

    Ha, figures the one supplement I take appears to do diddly squat. Sigh. I take 4,000 IUs daily, which is higher than the 1,000 IU low-dose group but 1/3 of the high-dose (those on the high-dose arm took 12,000). Unfortunately no dietary supplement has shown to have any effect on MS in clinical trials. - Dave

    High-Dose Vitamin D May Not Be Better than Low-Dose Vitamin D in Treating MS

    ST. PAUL, Minn. – Low vitamin D levels are associated with an increased risk of developing multiple sclerosis (MS), but the first randomized, controlled trial using high-dose vitamin D in MS did not find any added benefit over and above ongoing low-dose vitamin D supplementation, according to a study published in the October 25, 2011, issue of Neurology®, the medical journal of the American Academy of Neurology.

    “We did not find added benefit from high-dose vitamin D over and above ongoing low-dose vitamin D supplementation, but these results need to be confirmed with larger studies,” said Mark S. Stein, MBBS, PhD, FRACP, of The Royal Melbourne Hospital and The Walter and Eliza Hall Institute of Medical Research in Parkville, Australia.

    The six-month study involved 23 people with the relapsing-remitting form of MS. All of the participants received low-dose vitamin D (1,000 international units daily) to prevent any vitamin D deficiency. Half of the participants also received high-dose vitamin D2 to elevate their blood vitamin D to high levels (with a target serum 25-hydroxyvitamin D level of 130-175nM). The other half received a placebo high-dose.

    MRI scans of the participants’ brains were performed at the start of the study and again after four, five and six months. There was no significant difference between the two groups in the number of new abnormalities that had formed in the brain after six months and no significant difference in the change in the total volume of brain abnormalities.

    Four of the 11 people taking the high-dose vitamin D, or 37 percent, had a relapse where their MS symptoms worsened during the study, while none of the 12 people taking only low-dose vitamin D had any relapses.

    Stein noted that the study involved people who had MS for an average of six years. “It’s possible that studies of high-dose vitamin D at an earlier stage of MS may lead to different results,” he said.

    This study was supported by The Myer Foundation in Melbourne, Australia.

    The American Academy of Neurology, an association of more than 24,000 neurologists and neuroscience professionals, is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimer’s disease, stroke, migraine, multiple sclerosis, brain injury, Parkinson’s disease and epilepsy. For more information about the American Academy of Neurology, visit

    More detailed story:
    Dave Bexfield

  • #2
    I take 5000 iu a day and haven't noticed a change in the MS, but I do notice a change in fatigue levels. So I guess it does SOMETHING just not in regards to the progression of MS, its too bad it couldn't be so simple isn't it lol, take a supplement D3 and all is well.