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Old 05-07-2019, 05:31 PM
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Join Date: Jun 2008
Location: Albuquerque, NM
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Cannabis use by Patients with Multiple Sclerosis in Colorado

Christopher Domen et al
University of Colorado School of Medicine

Objective: To explore cannabis use among patients with multiple sclerosis (PwMS) treated at a large academic medical center in a state where cannabis is legal. Specifically, we examined: 1) prevalence of use, 2) patient characteristics of cannabis users (CUs) and non-users (NUs; e.g., demographics, disability status), 3) symptoms cannabis is used to manage, and 4) cannabis products used (e.g., combustable vs. edible).

Background: Studies suggest that cannabis may be useful for the management of symptoms like pain and muscle spasticity. However, few studies have explored the profile of PwMS who are CUs and the characteristics of their use, particularly in a state where cannabis is legal recreationally and medicinally

Design/Methods: PwMS completed a questionnaire via tablet computer assessing personal opinions about cannabis use, characteristics of cannabis use, sociodemographics, and MS history, as well as the Patient Determined Disease Steps (PDDS), Patient Reported Outcome Measure Information System (PROMIS-10), and Neuro-QoL ACGC v1.0 measures.

Results: Of 251 respondents, 38% were current CUs. No sociodemographic differences between CUs and NUs were found (p > 0.05), but CUs reported significantly higher disability compared to NUs on the PDDS (p ≤ 0.05). Among CUs, 57% categorized their use as strictly medicinal. Among strictly medicinal CUs, 91% use products that are not combusted/smoked and 83% reported using products with at least some CBD (vs. only THC). Strictly medicinal CUs also had significantly reduced self-reported physical health on the PROMIS-10 (p ≤ 0.05) and higher reported disability on the PDDS (p ≤ 0.01). CUs reported using cannabis most often to manage pain and insomnia, with 79% reporting that they experience no side-effects.

Conclusions:
Legalization efforts appear to be increasing the number of PwMS seeking out cannabis as a complimentaryalternative medicine, with CUs self-reporting that their products of choice are highly efficacious and noting minimal side-effects.
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