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Saw this the other day. HSCT is being used for other diseases and disorders with some success. - D
Novel therapy for Type 1 diabetes - autologous hematopoietic stem cell transplantation
Lirong Li1, Weiqiong Gu2, Dalong Zhu1
DOI: 10.1111/jdb.12002
Abstract
Type 1 diabetes is pathologically characterized by autoimmune insulitis-related islet β cell destruction. Although intensive insulin therapy for patients with type 1 diabetes can correct hyperglycemia, this therapy does not prevent all diabetes-related complications. Recent studies have shown that autologous hematopoietic stem cell transplantation (HSCT) is a new promising approach for the treatment of type 1 diabetes by reconstitution of immunotolerance and preservation of islet β cell function. Here we discuss the therapeutic efficacy and the potential mechanisms underlying the action of HSCT and other prospectives in the clinical management of type 1 diabetes.
http://onlinelibrary.wiley.com/doi/1...12002/abstract
Lirong Li1, Weiqiong Gu2, Dalong Zhu1
DOI: 10.1111/jdb.12002
Abstract
Type 1 diabetes is pathologically characterized by autoimmune insulitis-related islet β cell destruction. Although intensive insulin therapy for patients with type 1 diabetes can correct hyperglycemia, this therapy does not prevent all diabetes-related complications. Recent studies have shown that autologous hematopoietic stem cell transplantation (HSCT) is a new promising approach for the treatment of type 1 diabetes by reconstitution of immunotolerance and preservation of islet β cell function. Here we discuss the therapeutic efficacy and the potential mechanisms underlying the action of HSCT and other prospectives in the clinical management of type 1 diabetes.
http://onlinelibrary.wiley.com/doi/1...12002/abstract
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