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Autologous hematopoietic stem cell transplantation following alemtuzumab therapy in aggressive multiple sclerosis: A report of three cases
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Giacomo Boffa
, Elvira Sbragia, Anna Maria Raiola, ...
First Published August 25, 2020 Case Report
https://doi.org/10.1177/1352458520914818
Abstract
The management of multiple sclerosis patients with persistent disease activity under alemtuzumab treatment is not established yet. Concerns have been raised on the safety of autologous haematopoietic stem cell transplantation (aHSCT) after alemtuzumab treatment because of the risk of serious infectious adverse events. We report short-term safety and efficacy data from three patients treated with aHSCT following alemtuzumab treatment. Early adverse events were consistent with expected transplant toxicities. All patients were free of disease activity at the last follow-up. Our data suggest that aHSCT can be considered as a rescue treatment strategy for MS patients with persistent disease activity during alemtuzumab treatment.
NOTE: EDSS levels went down in all patients after being treated with HSCT. Case 1: EDSS 7.5 ---> 2. Case 2: EDSS 5.5 ----> 4.5. Case 3: EDSS 6 ----> 2.5.
Show all authors
Giacomo Boffa
, Elvira Sbragia, Anna Maria Raiola, ...First Published August 25, 2020 Case Report
https://doi.org/10.1177/1352458520914818
Abstract
The management of multiple sclerosis patients with persistent disease activity under alemtuzumab treatment is not established yet. Concerns have been raised on the safety of autologous haematopoietic stem cell transplantation (aHSCT) after alemtuzumab treatment because of the risk of serious infectious adverse events. We report short-term safety and efficacy data from three patients treated with aHSCT following alemtuzumab treatment. Early adverse events were consistent with expected transplant toxicities. All patients were free of disease activity at the last follow-up. Our data suggest that aHSCT can be considered as a rescue treatment strategy for MS patients with persistent disease activity during alemtuzumab treatment.
NOTE: EDSS levels went down in all patients after being treated with HSCT. Case 1: EDSS 7.5 ---> 2. Case 2: EDSS 5.5 ----> 4.5. Case 3: EDSS 6 ----> 2.5.