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HSCT as a first-line disease-modifying therapy in patients with ‘aggressive’ multiple sclerosis

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  • HSCT as a first-line disease-modifying therapy in patients with ‘aggressive’ multiple sclerosis

    Autologous haematopoietic stem cell transplantation as a first-line disease-modifying therapy in patients with ‘aggressive’ multiple sclerosis

    J Das, JA Snowden, J Burman
    First Published February 10, 2021 Research Article

    https://doi.org/10.1177/1352458520985238

    Abstract

    Background:
    Autologous haematopoietic stem cell transplantation (AHSCT) is an effective treatment for patients with multiple sclerosis (MS) who have highly active disease, despite the use of standard disease-modifying therapies (DMTs). However, the optimal time for offering AHSCT to patients with ‘aggressive’ MS is yet to be established.

    Objectives:
    The objective was to explore the safety and efficacy of AHSCT as a first-line DMT in patients with ‘aggressive’ MS.

    Methods:
    All patients with ‘aggressive’ MS who received AHSCT as a first-line DMT in five European and North American centres were retrospectively evaluated.

    Results:
    Twenty patients were identified. The median interval between diagnosis and AHSCT was 5 (1–20) months. All had multiple poor prognostic markers with a median pre-transplant Expanded Disability Status Scale (EDSS) score of 5.0 (1.5–9.5). After a median follow-up of 30 (12–118) months, the median EDSS score improved to 2.0 (0–6.5, p < 0.0001). No patient had further relapses. Three had residual magnetic resonance imaging (MRI) disease activities in the first 6 months post-transplant, but no further new or enhancing lesions were observed in subsequent scans.

    Conclusion:
    AHSCT is safe and effective as a first-line DMT in inducing rapid and sustained remission in patients with ‘aggressive’ MS.

    FULL ARTICLE (FREE): https://journals.sagepub.com/doi/ful...52458520985238
    Dave Bexfield
    ActiveMSers
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