STUDY: Brain pathology of a patient 7 years after HSCT for MS

[ActiveMSers]

This treatment is ballers for aggressive relapse remitting MS. Advanced secondary progressive MS, not so much, as this and other studies have found. - D

Brain pathology of a patient 7 years after autologous hematopoietic stem cell transplantation for multiple sclerosis

Annette Wundes, James D. Bowen, George H. Kraft, Kenneth R. Maravilla, Bernadette McLaughlin, Gloria von Geldern, George Georges, Richard A. Nash, Jian-Qiang Lu

DOI: http://dx.doi.org/10.1016/j.jns.2017.01.016

Abstract

Aggressive immunosuppression followed by autologous hematopoietic stem cell transplantation (aHSCT) can be an effective treatment for severe multiple sclerosis (MS), but not all stages of disease may benefit equally. The case of a 49-year-old woman with advanced secondary-progressive MS whose clinical course was not improved by aHSCT and who seven years after transplantation succumbed to complications of severe MS disease-related disability is presented. Autopsy findings of ongoing neurodegeneration despite only rare infiltrating T-lymphocytes illustrate that late MS disease may not represent a suitable disease stage for aHSCT.

[ActiveMSers]

The docs over at Bart's MS Blog had this to say about this result. - D

Here is a person with progressive MS, who had stem cell therapy. There disease continued to worsen over the next 4 years and sadly they died.*

This is a timely reminder that HSCT is not the solution for everyone. The data indicates that people with active relapsing Disease respond best.

http://multiple-sclerosis-research.b...is+Research%29