This is what Prof. Giovannoni recommends...
Postscript 1: I have been asked which of the anticholinergics used for MS-related bladder dysfunction are the safest. The table below indicates that Trospium is by far the least CNS penetrant; is the least lipid-soluble and the most positively charged. It is clear that oxybutynin is the worst. Tolterodine, darifenacin and solifenacin are in between.
Source: Chancellor M, Boone T. Anticholinergics for overactive bladder therapy: central nervous system effects. CNS Neurosci Ther. 2012;18(2):167-174. doi:10.1111/j.1755-5949.2011.00248.x
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Oxybutynin for urinary issues, is it safe?
I've been taking Oxybutynin at night for the last year or so to help prevent nighttime bathroom runs. So far it has been pretty effective. But now I may switch after reading this from Bart's MS....
https://multiple-sclerosis-research....t-is-your-abc/
Thoughts? What do you guys take?
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