STUDY: Vaccines do not increase the risk of MS

[ActiveMSers]

Vaccines and the Risk of Multiple Sclerosis and Other Central Nervous System Demyelinating Diseases

Annette Langer-Gould, MD, PhD1,2; Lei Qian, PhD1; Sara Y. Tartof, PhD1; Sonu M. Brara, MD2; Steve J. Jacobsen, MD, PhD1; Brandon E. Beaber, MD2; Lina S. Sy, MPH1; Chun Chao, PhD1; Rulin Hechter, MD, PhD1; Hung Fu Tseng, PhD, MPH1

JAMA Neurol. Published online October 20, 2014. doi:10.1001/jamaneurol.2014.2633

Importance: Because vaccinations are common, even a small increased risk of multiple sclerosis (MS) or other acquired central nervous system demyelinating syndromes (CNS ADS) could have a significant effect on public health.

Objective
To determine whether vaccines, particularly those for hepatitis B (HepB) and human papillomavirus (HPV), increase the risk of MS or other CNS ADS.

Design, Setting, and Participants
A nested case-control study was conducted using data obtained from the complete electronic health records of Kaiser Permanente Southern California (KPSC) members. Cases were identified through the KPSC CNS ADS cohort between 2008 and 2011, which included extensive review of medical records by an MS specialist. Five controls per case were matched on age, sex, and zip code.

Exposures
Vaccination of any type (particularly HepB and HPV) identified through the electronic vaccination records system.

Main Outcomes and Measures
All forms of CNS ADS were analyzed using conditional logistic regression adjusted for race/ethnicity, health care utilization, comorbid diseases, and infectious illnesses before symptom onset.

Results
We identified 780 incident cases of CNS ADS and 3885 controls; 92 cases and 459 controls were females aged 9 to 26 years, which is the indicated age range for HPV vaccination. There were no associations between HepB vaccination (odds ratio [OR], 1.12; 95% CI, 0.72-1.73), HPV vaccination (OR, 1.05; 95% CI, 0.62-1.78), or any vaccination (OR, 1.03; 95% CI, 0.86-1.22) and the risk of CNS ADS up to 3 years later. Vaccination of any type was associated with an increased risk of CNS ADS onset within the first 30 days after vaccination only in younger (<50 years) individuals (OR, 2.32; 95% CI, 1.18-4.57).

Conclusions and Relevance
We found no longer-term association of vaccines with MS or any other CNS ADS, which argues against a causal association. The short-term increase in risk suggests that vaccines may accelerate the transition from subclinical to overt autoimmunity in patients with existing disease. Our findings support clinical anecdotes of CNS ADS symptom onset shortly after vaccination but do not suggest a need for a change in vaccine policy.

[Suebee]

Recent study HPV vaccine Overall safe, but may unmask MS

Hi I was wondering if anyone has vaccinated their children with HPV vaccine? Obviously it is a very personal decision. But I was hoping to hear some MSers view points. Preventing cancer is an incredible thing, who doesn't want that for their kids?!?, but assurances it doesn't cause MS, but may unmask or trigger latent MS, is not reassuring to me - a person who has lived with it. My daughters have increased risks for MS because of my ms and their maternal grandmother's ms. In my thinking one does not want to trigger latent MS or unmask it. My daughters have high school, college, jobs, marriage, their own children ahead of them, and if they are going develop MS, I certainly don't want to hasten it. But there is a tear jerker ad on T.V. (no not the tysbri dive queen, no not the meningitis teary-eyed mom) for the HPV vaccine showing kids blaming their parents for getting cancer and reminding the viewer that there was something that could have prevented. Bravo marketers! (I say dirty pool)
Anyway, here is

link to full article
http://jama.jamanetwork.com/article....icleid=2088853

Quadrivalent HPV Vaccination and Risk of Multiple Sclerosis and Other Demyelinating Diseases of the Central Nervous System AMA. 2015;313(1):54-61. doi:10.1001/jama.2014.16946.

[AMFADVENTURES]

You're right to be concerned Suebee. Although the HPV vaccines appear to use inactivated virus, possibly less problematic, studies on people genetically at risk for MS seem to be missing. Having said that though, you might want to check with a reputable MS specialist or clinic - or two.

BTW, thanks for all of the great research you regularly do, personally I love it.

Larry

[Lmh]

Vaccinations

I agree with you Suebee! My daughter was vaccinated with the HPV vaccine, and knowing what I do now, regret that decision. Neither my MS nor her Aunt's was diagnosed yet. Plus, the possible link to future MS development surfaced several years later.
I also like your posts!😊

[ActiveMSers]

Here's another study, just released this past week. While the science doesn't link vaccines to MS, I am conflicted. My symptoms all started after a Hep B vaccination prior to a trip to Vietnam and Cambodia. Coincidence? Probably. But still, it bugs me. - D

----------------

J Neurol. 2016 Sep 7. [Epub ahead of print]
Vaccines and multiple sclerosis: a systematic review.

Mailand MT, Frederiksen JL.

Author information:
•University of Copenhagen, Copenhagen, Denmark.
•Department of Neurology, University of Copenhagen, Rigshospitalet Glostrup, Nordre Ringvej 57, 2600, Glostrup, Denmark.

Abstract

Vaccinations are often the most effective tool against some disease known to mankind. This study offers a literature review on the role of vaccines regarding the risk of developing multiple sclerosis (MS) and MS relapse. The method used in this study is a systematic literature review on the database PubMed. The study found no change in risk of developing multiple sclerosis (MS) after vaccination against hepatitis B virus, human papillomavirus, seasonal influenza, measles-mumps-rubella, variola, tetanus, Bacillus Calmette-Guérin (BCG), polio, or diphtheria. No change in risk of relapse was found for influenza. Further research is needed for the potential therapeutic use of the BCG vaccine in patients in risk of developing MS and for the preventive potential of the tetanus and diphtheria vaccine.

PMID: 27604618 [PubMed - as supplied by publisher]

[Suebee]

Dave, thanks for the post. Yes I'm bugged too. It is hard to decipher from the abstract (full doc is for fee) if authors are using a similar vocabulary as the other vaccine studies. But I'm guessing so. To connect a vaccine to someone who has "developed " ms, studies put specific parameters on the defination of "developed" and then "adjust" for percentages of people in population who would normally develop ms. We don't have to be scientists to know that this is a higher standard than mere antedotal evidence. I understand why one needs to define "developed" but I think it is extremely misleading to claim vaccines to do not lead one to "develop" ms, and bury deep inside article that it may hasten ms or "unmask" it, but they were going to "develop" ms anyway! The later does not get passed along and people are unaware "developed" is a term of art and not common language.

[Suebee]

France says legal standard allows finding of hep b vaccine connection to MS

French journal points out that although a scientific connection has not been proven between hep b vaccine and MS, a legal standard does permit a causal connection to be made.
http://www.ncbi.nlm.nih.gov/m/pubmed...725231/related

[Suebee]

Holy toledo batman, dog vaccine could be dangerous to MS patients!!!

I had my dog get her routine vaccinations today and my vet felt the intra nasal live bordetella vaccine (kennel cough) wasn't a good idea because 1) it was live and 2) intra nasal means my dog could snot it on me and trigger an unwanted immune response in me.

My dog has gotten the intra-nasal before, and I will need to check my notes to see if it matches up with my slide. Regardless, I agreed no live vaccine. You can get IM dead virus vaccine for bordetella for pets!

Dr. Google confirms one should be cautious with live bordetalla vaccines for pets if you have an immune issue. see excerpt and link at bottom.

AGAIN, has anyone every heard this before? For goodness sake, we work so hard to manage our MS with DMDs, sleep, diet, mediation - shouldn't we all know that the intra-nasal vaccine for our dog might trigger an MS flare and it is better to just vaccinate our dogs with the dead virus vaccine?!?!

"In households with individuals with a weakened immune system (e.g. HIV/AIDS, transplant or cancer patients), some measures that can be taken to help reduce the risk of transmission of Bordetella from pets include:

Avoid boarding dogs at kennels or veterinary clinics. If boarding cannot be avoided, ensure that dogs have been properly vaccinated against Bordetella bronchiseptica, and that the kennel or clinic requires all other dogs boarding there to be vaccinated as well.
Avoid obtaining a dog directly from from an animal shelter.
Wash your hands regularly after handling any dog, particularly if you’ve touched the dog’s nose or mouth.
Don’t allow dogs to lick your face or hands.
The Bordetella vaccine for dogs is a modified live vaccine, meaning that a live but less virulent (pathogenic) form of the bacterium is administered to "prime" the immune system against regular Bordetella. Concern has been raised by some people that exposure to the vaccine strain could actually cause disease in high-risk individuals, whose immune systems might be unable to fight off even this "weaker" version of the bacteria. It is unclear whether exposure to the vaccine strain actually poses any risk. Nonetheless, it is reasonable to pay extra attention to avoiding contact with the dog’s face for a day or two after vaccination. Also, it is probably wise for immunocompromised owners to not hold the dog when it is being vaccinated, in order to reduce the risk of exposure to the vaccine."


from http://www.wormsandgermsblog.com/200...h-from-my-dog/

[Suebee]

Oxford Journal - live animal vaccines pose risk to humans

Additional esoteric info on dog vaccines for ones who are interested--- in 2003, the Oxford Journal of medicine published an article that said vet vaccines are not monitored or tracked for causing illness in humans. It made the following observation:

"With the advent of aerosol vaccination in veterinary clinics for companion animals, human exposure to B. bronchiseptica [1 strain of kennel cough] has likely increased in recent years. Physicians should ask patients presenting with pertussis-like illness whether they have visited a veterinary clinic or have been exposed to a sick or recently vaccinated animal during the week before the onset of symptoms. If the potential for exposure to B. bronchiseptica is present, performance of cultures should be considered before antibiotics are administered.

No special precautions to avoid human exposure are routinely taken during administration of this aerosol animal vaccine. .... Even when administered properly, there may be opportunity for human exposure, especially if the animal sneezes, which is a common occurrence after intranasal administration of a liquid. In addition, the animal may be able to transmit the vaccine strain during the period of active infection."
link to Oxford Journal article : http://cid.oxfordjournals.org/content/37/3/407.full

[Suebee]

hpv vaccine data

Came across this recent memo from The American Pediatric Society that there has been a statistical connection observed between the HPV vaccine and premature menopause...
as a mom of girls, i wanted to post...
https://www.acpeds.org/the-college-s...avirus-vaccine

[Suebee]

Opinion of Ct of EU on Hep B Vaccine to MS

Under a legal standard (not a medical study) Ct of EU found causal connection between Hep B vaccine and MS.
https://curia.europa.eu/jcms/upload/...cp170066en.pdf

I think this case illustrates that although a causal connection to MS was not found through a medical study, the connection between Heb B and MS has been legally documented, and although rare, it does exist. I feel we should be allowed to make informed decisions as to whether we receive a vaccine with such risk, especially when there is strong history of MS in one's family. My children's pediatricians never told me there was a risk with this vaccine.