No announcement yet.

Current status of neuroprotective and neuroregenerative strategies in MS: A systematic review

  • Filter
  • Time
  • Show
Clear All
new posts

  • Current status of neuroprotective and neuroregenerative strategies in MS: A systematic review

    Current status of neuroprotective and neuroregenerative strategies in multiple sclerosis: A systematic review

    Show all authors
    Jessica R Allanachǂ, John W. Farrell, IIIǂ, Miceline Mésidorǂ, ...
    First Published April 19, 2021



    Immune-mediated demyelination and consequent degeneration of oligodendrocytes and axons are hallmark features of multiple sclerosis (MS). Remyelination declines in progressive MS, causing permanent axonal loss and irreversible disabilities. Strategies aimed at enhancing remyelination are critical to attenuate disease progression.


    We systematically reviewed recent advances in neuroprotective and regenerative therapies for MS, covering preclinical and clinical studies.


    We searched three biomedical databases using defined keywords. Two authors independently reviewed articles for inclusion based on pre-specified criteria. The data were extracted from each study and assessed for risk of bias.


    Our search identified 7351 studies from 2014 to 2020, of which 221 met the defined criteria. These studies reported 262 interventions, wherein 92% were evaluated in animal models. These interventions comprised protein, RNA, lipid and cellular biologics, small molecules, inorganic compounds, and dietary and physiological interventions. Small molecules were the most highly represented strategy, followed by antibody therapies and stem cell transplantation.


    While significant strides have been made to develop regenerative treatments for MS, the current evidence illustrates a skewed representation of the types of strategies that advance to clinical trials. Further examination is thus required to address current barriers to implementing experimental treatments in clinical settings.

    Dave Bexfield

  • #2
    Wow! Lots here in this review. At first pass, the comment on neuropeotective aspect of salavix jumps out: "the ∆-9-tetrahydrocannabinol (THC) and cannabidiol (CBD)-based medication, Sativex®, improved motor function, reduced glial scar formation, and protected myelin and axons in a viral demyelination model.26 Sativex is currently approved by Health Canada to treat MS neuropathic pain and spasticity in adults; these preclinical results suggest the treatment may also be neuroprotective.26"


    • #3
      Other interesting take aways: Omega 3 rich diet, fasting, exercise, electroaccupuncture all have positive effects on MSers... table 8

      Melatonin, T3, vit D have benefits for MSers ... table 4

      And several non pharmaceutical approaches looked promising :
      Cucurbita maxima (a type squash);
      anthocyanins (pigments that give red, purple, and blue plants their rich coloring); Epimedium flavonoids (Chinese flowering plant); and Propenals from a type of spruce tree sap
      ... see foot notes 92-96
      Last edited by Suebee; 05-12-2021, 09:22 PM.