Fatigue in Multiple Sclerosis: Misconceptions and Future Research Directions

[Suebee]

Awesome study, thanks for posting this! (I personally have coined my own word for MS fatigue that is can't be stated on a public forum. )
Your posted artice references that some objective ways to measure muscle fatigue have been developed! Hallelujah [It's not in your head!] see footnote #50 -

"The present study demonstrates greater muscle fatigue and delayed force recovery in MS patients compared to controls. This fatigue was not due to central fatigue, peripheral fatigue of the motor nerve or myoneural junction, or from impaired excitability of the muscle membrane. Hence, the site of impairment during intermittent tetanic stimulation apparently lies within the muscle itself..... The correlation of clinical disability ratings to intramuscular fatigue in MS suggests that individuals with upper motor neuron lesions have secondary changes in muscle..."

link to cited article in footnote #50 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2733338/

[AMFADVENTURES]

Fatigue in Multiple Sclerosis: Misconceptions and Future Research Directions

Personally I think the word fatigue is a misnomer when applied to the debilitating symptom many MSers experience. This article attempts to address that by redefining fatigue. Perhaps what we really need is a new word.

Regardless, this article has a lot of good information on both indicated and theoretical causes of the symptom. Be sure to read the whole article, in particular, Factors Contributing to Fatigue in MS, the abstract alone does not do the article justice.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969300/