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STUDY: Exercise does not lower the risk of developing MS

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  • STUDY: Exercise does not lower the risk of developing MS

    With nearly 200,000 participants (all women) and 20 years of data, this is pretty conclusive. And I would imagine the same would apply to men, although men were not studied. According to the lead researcher: “Overall, there was no consistent association of exercise at any age and MS. Exercise has been shown to be beneficial to people with the disease, but it seems unlikely that exercise protects against the risk of developing MS.” - D

    Physical activity and the incidence of multiple sclerosis

    Kirsten S. Dorans, ScD, Jennifer Massa, ScD, Tanuja Chitnis, MD, Alberto Ascherio, MD, DrPH and Kassandra L. Munger, ScD

    Published online before print September 28, 2016, doi: http:/​/​dx.​doi.​org/​10.​1212/​WNL.​0000000000003260
    Neurology 10.1212/WNL.0000000000003260


    Objective: To study whether physical activity during adulthood or early life is associated with multiple sclerosis (MS) incidence in 2 prospective cohorts of women.

    Methods: Women in the Nurses' Health Study (NHS) (n = 81,723; 1986–2004) and NHS II (n = 111,804; 1989–2009) reported recent physical activity at baseline and in selected follow-up questionnaires. Using this information, we calculated total metabolic equivalent hours of physical activity per week, a measure of energy expenditure. There were 341 confirmed MS cases with first symptoms after baseline. Participants also reported early-life activity. To estimate relative rates (RRs) and 95% confidence intervals (CIs), we used Cox proportional hazards models, adjusting for age, latitude of residence at age 15, ethnicity, smoking, supplemental vitamin D, and body mass index at age 18.

    Results: Compared with women in the lowest baseline physical activity quartile, women in the highest quartile had a 27% reduced rate of MS (RRpooled = 0.73, 95% CI 0.55–0.98; p-trend 0.08); this trend was not present in 6-year lagged analyses. Change in physical activity analyses suggested that women reduced activity before onset of MS symptoms. In NHS and NHS II, higher strenuous activity at ages 18–22 years was weakly associated with a decreased MS rate. However, in NHS II, total early-life activity at ages 12–22 was not associated with MS.

    Conclusions: Though higher physical activity at baseline was weakly associated with lower MS risk, this may have been due to women reducing physical activity in response to subclinical MS.

    Dave Bexfield