STUDY: How Running Improves Memory in MS

[ActiveMSers]

A pilot study of the effects of running training on visuospatial memory in MS: A stronger functional embedding of the hippocampus in the default-mode network?

Marijn Huiskamp, Lousin Moumdjian, Paul van Asch, ...
First Published July 18, 2019

https://doi.org/10.1177/1352458519863644

Abstract

Background/objective:
Endurance exercise can improve memory function in persons with multiple sclerosis (pwMS), but the effects on hippocampal functioning are currently unknown. We investigated the effects of a running intervention on memory and hippocampal functional connectivity in pwMS.

Methods/results:
Memory and resting-state functional magnetic resonance imaging (fMRI) data were collected in a running intervention (n = 15) and waitlist group (n = 14). Visuospatial memory improvement was correlated to increased connectivity between the hippocampus and the default-mode network (DMN) in the intervention group only.

Conclusion:
As a result of endurance exercise, improvements in visuospatial memory may be mediated by a stronger functional embedding of the hippocampus in the DMN.

Keywords Multiple sclerosis, cognitive rehabilitation, endurance exercise, functional connectivity, hippocampus, default-mode network

[ActiveMSers]

FYI

Visuospatial function refers to cognitive processes necessary to "identify, integrate, and analyze space and visual form, details, structure and spatial relations" in more than one dimension. Visuospatial skills are needed for movement, depth and distance perception, and spatial navigation. Wikipedia