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Yes, it's just mice. And just female mice. But "demyelination levels decreased in the EAE-EX1 group compared to the EAE group" and that "HIIT increased Klotho and PLP levels and improved clinical outcomes in the in mice with MS." What does this mean? If you are a female mouse, you best be doing HIIT! And maybe if you are a human MSer, hedge your bets and do HIIT! -D
Journal: JOURNAL OF APPLIED EXERCISE PHYSIOLOGY (JOURNAL OF SPORTS SCIENCE) fall 2019-winter 2020 , Volume 15 , Number 30 ; Page(s) 15 To 29.
Paper: The Effect of High Intensity Interval Training Preconditioning on Klotho and TNF-α Female Mice with Multiple Sclerosis
Author(s): Farahmand Fatane, Nourshahi Maryan*, Soleimani Maryam, Rajabi Hamid, Power Kevin
* Department of Biological Sciences in Sport and Health, Faculty of Sports Sciences and Health, Shahid Beheshti University, Tehran, Iran
Abstract:
Background Purpose Exercise activity plays an important role in increasing biomarkers such as Klotho and PLP and improves clinical outcome in mice with MS. In the present study, we evaluated whether 6 weeks of high-intensity interval training (HIIT) increases Klotho or PLP levels and decreased TNF-α in cerebellum tissue.
Methodology: Animals were divided into two groups of training (EX) and control (Con). After 4 weeks, the exercise and control groups were divided into two groups and EAE was induced in half of the animals in the control and EX groups. In the EX-6 weeks group after 4 weeks of training, EAE induction and training protocol continued until the sixth week. In the EX-4 weeks group after 4 weeks of training, EAE was induced and the training was stopped.
Results: Klotho and PLP levels increased in the EAE-EX1 group compared to the EAE and EAE-EX2 groups (P≤ 0. 0001). Also, demyelination levels decreased in the EAE-EX1 group compared to the EAE group (P≤ 0. 007). TNF-α concentration decreased in both EAE-exercise groups (P≤ 0. 0001).
Conclusion: The results of this study showed that HIIT increased Klotho and PLP levels and improved clinical outcomes in the in mice with MS.
Journal: JOURNAL OF APPLIED EXERCISE PHYSIOLOGY (JOURNAL OF SPORTS SCIENCE) fall 2019-winter 2020 , Volume 15 , Number 30 ; Page(s) 15 To 29.
Paper: The Effect of High Intensity Interval Training Preconditioning on Klotho and TNF-α Female Mice with Multiple Sclerosis
Author(s): Farahmand Fatane, Nourshahi Maryan*, Soleimani Maryam, Rajabi Hamid, Power Kevin
* Department of Biological Sciences in Sport and Health, Faculty of Sports Sciences and Health, Shahid Beheshti University, Tehran, Iran
Abstract:
Background Purpose Exercise activity plays an important role in increasing biomarkers such as Klotho and PLP and improves clinical outcome in mice with MS. In the present study, we evaluated whether 6 weeks of high-intensity interval training (HIIT) increases Klotho or PLP levels and decreased TNF-α in cerebellum tissue.
Methodology: Animals were divided into two groups of training (EX) and control (Con). After 4 weeks, the exercise and control groups were divided into two groups and EAE was induced in half of the animals in the control and EX groups. In the EX-6 weeks group after 4 weeks of training, EAE induction and training protocol continued until the sixth week. In the EX-4 weeks group after 4 weeks of training, EAE was induced and the training was stopped.
Results: Klotho and PLP levels increased in the EAE-EX1 group compared to the EAE and EAE-EX2 groups (P≤ 0. 0001). Also, demyelination levels decreased in the EAE-EX1 group compared to the EAE group (P≤ 0. 007). TNF-α concentration decreased in both EAE-exercise groups (P≤ 0. 0001).
Conclusion: The results of this study showed that HIIT increased Klotho and PLP levels and improved clinical outcomes in the in mice with MS.
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