Exercise and the brain in multiple sclerosis

[ActiveMSers]

This is a big-big deal for MSers. Unfortunately this is not a free article. -D

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Exercise and the brain in multiple sclerosis

Brian M Lozinski, V Wee Yong
First Published October 30, 2020 Review Article
https://doi.org/10.1177/1352458520969099

Article information

Abstract

While people with multiple sclerosis (PwMS) historically were advised to avoid physical activity to reduce symptoms such as fatigue, they are now encouraged to remain active and to enlist in programs of exercise. However, despite an extensive current literature that exercise not only increases physical well-being but also their cognition and mental health, many PwMS are not meeting recommended levels of exercise. Here, we emphasize the impact and mechanisms of exercise on functional and structural changes to the brain, including improved connectome, neuroprotection, neurogenesis, oligodendrogenesis, and remyelination. We review evidence from animal models of multiple sclerosis (MS) that exercise protects and repairs the brain, and provide supportive data from clinical studies of PwMS. We introduce the concept of MedXercise, where exercise provides a brain milieu particularly conducive for a brain regenerative medication to act upon. The emphasis on exercise improving brain functions and repair should incentivize PwMS to remain physically active.

[Pistachio]

Here's a bit more.....hopefully you can enlarge it on your devices to make it readable.


https://www.deepdyve.com/lp/sage/exe...Ho9wq?key=sage

[ActiveMSers]

Pistachio, thanks so much! The first page of the study is better than nothing. Here's another interesting article. Not MS specific, but definitely relevant. -D

BRAIN BENEFITS
3 PROFOUND IMPACTS EXERCISE HAS ON THE BRAIN

Our brains will thank us for it in years to come.

REGULAR EXERCISE CHANGES THE STRUCTURE OF OUR BODIES’ TISSUES IN OBVIOUS WAYS, such as reducing the size of fat stores and increasing muscle mass. Less visible, but perhaps even more important, is the profound influence exercise has on the structure of our brains – an influence that can protect and preserve brain health and function throughout life. In fact, some experts believe that the human brain may depend on regular physical activity to function optimally throughout our lifetime.

https://www.inverse.com/mind-body/ex...-structure/amp