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Physical activity, sedentary behavior, and aerobic capacity in persons with multiple sclerosis
Robert W. Motla, , , Brian M. Sandroffb, , Lara A. Piluttic, , Rachel E. Klarend, , Tracy Baynarde, , Bo Fernhallf,
Highlights
•Aerobic fitness is reduced in persons with multiple sclerosis (MS).
•Structured exercise training improves aerobic capacity in MS.
•Less is known about physical activity, sedentary time, and aerobic fitness in MS.
•Physical activity, but not sedentary time, correlated with aerobic fitness in MS.
•Interventions should target physical activity for improving aerobic capacity in MS.
Abstract
Background
There is substantial evidence that exercise training improves aerobic capacity among people with multiple sclerosis (MS), but less is known about the associations between physical activity and sedentary behaviors with aerobic capacity.
Objective
This study examined if objectively-measured moderate-to-vigorous (MVPA) and light (LPA) physical activity and sedentary behavior were associated with peak aerobic capacity (VO2peak) measured using an established protocol for conducting a maximal, incremental exercise test in persons with MS.
Methods
The study involved a cross-sectional, observational study design and included 49 persons with MS. Participants wore an accelerometer around the waist during the waking hours for a 7-day period as a measure of physical activity and sedentary behaviors, and completed a maximal, incremental exercise test on an electronically-braked, computer-controlled cycle ergometer with open-circuit spirometry for measuring VO2peak.
Results
VO2peak was significantly correlated with MVPA (r*=*0.53, p*<*0.001) and LPA (r*=*0.39, p*<*0.01), but not sedentary behavior (r*=*−*0.12, p*=*0.44). Linear regression analysis indicated that MVPA (B*=*0.19, SE B*=*0.04, β*=*0.51, p*<*0.001) and LPA (B*=*0.02, SE B*=*0.01, β*=*0.30, p*<*0.05), but not sedentary behavior (B*=*−*0.01, SE B*=*0.01, β*=*−*0.14, p*=*0.26), explained significant variance in VO2peak (R2*=*0.40).
Conclusion
We provide the first evidence that MVPA and LPA represent concurrent correlates of VO2peak and both could be targeted for improving aerobic capacity in persons with MS.
Robert W. Motla, , , Brian M. Sandroffb, , Lara A. Piluttic, , Rachel E. Klarend, , Tracy Baynarde, , Bo Fernhallf,
Highlights
•Aerobic fitness is reduced in persons with multiple sclerosis (MS).
•Structured exercise training improves aerobic capacity in MS.
•Less is known about physical activity, sedentary time, and aerobic fitness in MS.
•Physical activity, but not sedentary time, correlated with aerobic fitness in MS.
•Interventions should target physical activity for improving aerobic capacity in MS.
Abstract
Background
There is substantial evidence that exercise training improves aerobic capacity among people with multiple sclerosis (MS), but less is known about the associations between physical activity and sedentary behaviors with aerobic capacity.
Objective
This study examined if objectively-measured moderate-to-vigorous (MVPA) and light (LPA) physical activity and sedentary behavior were associated with peak aerobic capacity (VO2peak) measured using an established protocol for conducting a maximal, incremental exercise test in persons with MS.
Methods
The study involved a cross-sectional, observational study design and included 49 persons with MS. Participants wore an accelerometer around the waist during the waking hours for a 7-day period as a measure of physical activity and sedentary behaviors, and completed a maximal, incremental exercise test on an electronically-braked, computer-controlled cycle ergometer with open-circuit spirometry for measuring VO2peak.
Results
VO2peak was significantly correlated with MVPA (r*=*0.53, p*<*0.001) and LPA (r*=*0.39, p*<*0.01), but not sedentary behavior (r*=*−*0.12, p*=*0.44). Linear regression analysis indicated that MVPA (B*=*0.19, SE B*=*0.04, β*=*0.51, p*<*0.001) and LPA (B*=*0.02, SE B*=*0.01, β*=*0.30, p*<*0.05), but not sedentary behavior (B*=*−*0.01, SE B*=*0.01, β*=*−*0.14, p*=*0.26), explained significant variance in VO2peak (R2*=*0.40).
Conclusion
We provide the first evidence that MVPA and LPA represent concurrent correlates of VO2peak and both could be targeted for improving aerobic capacity in persons with MS.