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STUDY: Cycle ergometer training enhances plasma interleukin-10 in multiple sclerosis

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  • STUDY: Cycle ergometer training enhances plasma interleukin-10 in multiple sclerosis

    Neurological Sciences

    Cycle ergometer training enhances plasma interleukin-10 in multiple sclerosis

    Authors
    Alison Barry, Owen Cronin, Aisling M. Ryan, et al

    Abstract

    The objective was to determine plasma levels of pro- (IL-12p70/IL-6) and anti-inflammatory (IL-10) cytokines before and after cycle ergometer training in healthy control (HC) and people with multiple sclerosis (pwMS), and to correlate plasma cytokines with physical/mental health.

    Study participants cycled for 30 min at 6575% age-predicted maximal heart rate, twice a week for 8 weeks during supervised sessions. We determined that plasma IL-10 expression was lower in pwMS, compared to HCs, and that exercise augmented IL-10 in pwMS to baseline levels in HCs. Furthermore, plasma isolated from pwMS displayed enhanced expression of the pro-inflammatory cytokines IL-12p70/IL-6. Plasma cytokine signatures correlated with physical/mental health.

    Overall, this study highlights the potential of a short-term exercise programme to regulate circulating cytokine profiles with relevance to pwMS.
    Dave Bexfield
    ActiveMSers
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