Researchers are proposing a randomized controlled trial to see just how effective exercise is in MS. So far the results have been impressive (and posted throughout this forum), but the studies have been small and not randomized. Expanding this to an RDC is critical in order to have exercise be a core treatment for everyone with MS. - Dave
Mult Scler. 2011 Jun 17. [Epub ahead of print]
Cognitive dysfunction and multiple sclerosis: developing a rationale for considering the efficacy of exercise training.
Motl RW, Sandroff BM, Benedict RH.
Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, USA.
Cognitive impairment is a prevalent, disabling, and poorly managed consequence of multiple sclerosis (MS). This underscores the importance of considering alternative approaches, such as exercise training, for managing cognitive impairment in persons with MS. The consideration of exercise training is warranted based on evidence summarized in literature reviews and meta-analyses that (1) aerobic fitness, physical activity, and exercise training are associated with better cognitive function in older adults; and (2) exercise training has comparable effects on mobility and quality of life outcomes in older adults and persons with MS. To date, research examining aerobic fitness, physical activity, and exercise training effects on cognition in MS is nascent and mostly includes cross-sectional designs that provide preliminary evidence for a well-designed randomized controlled trial (RCT). We believe that a future RCT should adopt research methodologies and practices from gerontology when examining exercise training and cognition in MS. This will maximize the potential for successfully generating a body of knowledge on exercise training and cognition with the potential for impacting the lives of persons with MS.
Mult Scler. 2011 Jun 17. [Epub ahead of print]
Cognitive dysfunction and multiple sclerosis: developing a rationale for considering the efficacy of exercise training.
Motl RW, Sandroff BM, Benedict RH.
Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, USA.
Cognitive impairment is a prevalent, disabling, and poorly managed consequence of multiple sclerosis (MS). This underscores the importance of considering alternative approaches, such as exercise training, for managing cognitive impairment in persons with MS. The consideration of exercise training is warranted based on evidence summarized in literature reviews and meta-analyses that (1) aerobic fitness, physical activity, and exercise training are associated with better cognitive function in older adults; and (2) exercise training has comparable effects on mobility and quality of life outcomes in older adults and persons with MS. To date, research examining aerobic fitness, physical activity, and exercise training effects on cognition in MS is nascent and mostly includes cross-sectional designs that provide preliminary evidence for a well-designed randomized controlled trial (RCT). We believe that a future RCT should adopt research methodologies and practices from gerontology when examining exercise training and cognition in MS. This will maximize the potential for successfully generating a body of knowledge on exercise training and cognition with the potential for impacting the lives of persons with MS.
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